NFL Picks Today: 6 Matchups to Watch Sunday, September 20, 2026
Sunday's ASA NFL board features six Week 2 matchups, including four games in the early window and two afternoon games. Carolina visits Atlanta, Philadelphia travels to Tennessee, Green Bay faces the Jets, Cleveland visits Tampa Bay, Jacksonville heads to Denver and Seattle meets Arizona in an NFC West matchup.
Six Week 2 Matchups on the ASA Radar
Carolina Panthers at Atlanta Falcons
Panthers at Falcons
Carolina and Atlanta enter Sunday searching for their first victory after very different Week 1 losses. Carolina surrendered 59 points in a 59-37 loss to Chicago, while Atlanta fell 20-13 at Pittsburgh.
Atlanta's quarterback situation makes this one of the most information-sensitive games on Sunday's board. Tua Tagovailoa missed Wednesday practice with an oblique injury, while Michael Penix Jr. and Cooper Rush both practiced fully.
Atlanta is also monitoring guard Chris Lindstrom and cornerback A.J. Terrell, making Friday's final injury report particularly important before evaluating the Falcons at the current number.
Do not finalize this handicap until Atlanta's quarterback situation becomes clearer. The identity and health of the Falcons' starter can affect the spread, total and offensive expectations enough to materially change the value of the game.
Philadelphia Eagles at Tennessee Titans
Eagles at Titans
Philadelphia enters Week 2 at 1-0 after surviving Washington 24-22, while Tennessee returns home at 0-1 after a 23-10 loss to the Jets.
Those Week 1 results naturally create different market perceptions. Philadelphia won while Tennessee struggled offensively, but bettors should be careful about treating one Sunday as a complete representation of either team.
The Eagles now leave home for their first road game. Tennessee needs to prove it can create more sustained offense while avoiding the negative situations that made its opener difficult.
Determine whether Tennessee's offensive problems were structural or correctable Week 1 issues. Philadelphia may be the stronger team, but road favorites still need to justify the points being asked of bettors.
Green Bay Packers at New York Jets
Packers at Jets
Green Bay travels to New York looking to rebound from a 39-22 loss at Minnesota, while the Jets return home 1-0 after beating Tennessee 23-10.
The Jets produced one of Week 1's strongest defensive performances, allowing only 195 total yards. The question for bettors is how much of that result reflects the quality of New York's defense and how much came from Tennessee's offensive limitations.
Green Bay also has several defensive players appearing on the early injury report, making availability another important variable before kickoff.
The biggest question is whether the Jets' Week 1 defensive performance travels against a different offensive matchup. Green Bay's availability on defense and ability to avoid another slow start should also be monitored.
Cleveland Browns at Tampa Bay Buccaneers
Browns at Buccaneers
Cleveland and Tampa Bay both enter Week 2 at 0-1. The Browns are trying to recover from a 34-10 loss at Jacksonville, while Tampa Bay fell 33-27 at Cincinnati.
Cleveland's Week 1 result raises immediate questions about offensive efficiency and protection. The Browns' early injury report also includes multiple offensive linemen, which makes Friday's practice statuses especially important.
Tampa Bay was considerably more productive offensively in its opener, but allowing 33 points creates defensive questions of its own.
Cleveland's offensive-line availability is central to this matchup. Confirm the final injury report before evaluating whether the Browns can protect well enough to sustain offense against Tampa Bay.
Jacksonville Jaguars at Denver Broncos
Jaguars at Broncos
Jacksonville enters Week 2 with momentum after beating Cleveland 34-10, while Denver returns home looking for answers after losing 31-10 at Kansas City on Monday night.
That scheduling difference matters. Jacksonville has a normal week of preparation, while Denver comes off a Monday night road game and operates on a shorter turnaround.
The Broncos' early injury report also deserves attention. Running back RJ Harvey and wide receiver Marvin Mims Jr. missed Wednesday practice, while Jacksonville had several offensive starters limited.
Avoid automatically upgrading Jacksonville because of one dominant victory or downgrading Denver because of one poor performance. Rest, Denver's home environment and the final injury reports all need to be incorporated into the number.
Seattle Seahawks at Arizona Cardinals
Seahawks at Cardinals
Sunday's selected board closes with an NFC West matchup between two 1-0 teams. Arizona opened its season by beating the Chargers 26-14, while Seattle also enters Week 2 unbeaten.
The most important early-week development is Seattle quarterback Sam Darnold's status. Darnold did not practice Wednesday, making his progression through the remainder of the week a major variable for both the side and total.
Seattle also has several additional players on the injury report, including offensive linemen and receiver Cooper Kupp, while Arizona enters its home opener with the opportunity to build on an impressive Week 1 road victory.
Quarterback availability comes first. If Darnold's status changes, the betting market can move quickly. Wait for clearer information before treating an early Seattle-Arizona number as final.
Don't Let One Sunday Rewrite the Entire NFL
Separate Signal From Noise
Jacksonville's 34-10 win and Carolina's 59-point defensive collapse matter, but one game remains a small sample.
Quarterbacks Move Markets
Atlanta and Seattle have quarterback situations worth monitoring closely before Sunday's final numbers settle.
Watch the Trenches
Cleveland's offensive-line injuries and Green Bay's defensive availability could matter more than broad Week 1 narratives.
Price Over Prediction
The objective is not simply identifying which team is more likely to win. The objective is determining whether the available spread, moneyline or total offers value.
Re-check Friday injury designations and Sunday inactive lists before finalizing the card. Atlanta's quarterback situation, Sam Darnold's availability, Cleveland's offensive line and the Denver/Jacksonville skill-position injuries are among the developments capable of materially changing these handicaps.
Six Games to Analyze — Only the Best Need to Make the Card
Sunday gives ASA six NFL matchups ranging from divisional games to bounce-back situations and injury-sensitive markets. Premium selections are reserved for the games where the matchup, information and available betting number create enough value to qualify.
Sports betting involves financial risk. Advanced Sports Advisors provides sports betting analysis, handicapping opinions and informational content. No pick, prediction or past result guarantees future performance. Verify final injury reports, inactive lists, weather and betting markets before making any wagering decision.